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Vertex Pharmaceuticals
Oxford, United Kingdom
13 days ago
Vertex Pharmaceuticals
Oxford, United Kingdom
25 days ago


Job Description

General Summary

Vertex is currently seeking a Contract Research Scientist with a strong background in hydrogen deuterium exchange (HDX), native or structural mass spectrometry (MS) to join our multidisciplinary mechanistic MS team.

This 15 month position presents a unique opportunity to work at the cutting edge of drug discovery, developing and applying innovative structural MS approaches to answer key questions about mechanistic biology and compound-target interactions. Research Scientists in the mechanistic MS team work at the interface of multiple disciplines - chemistry, cellular biology, structural biology and biophysics. We are imbedded in wider diseases teams in order to have impact across all stages of the drug discovery pipeline

Candidates will have a broad background in MS and previous experience developing methods or approaches in HDX, native MS, structural/mechanistic MS or using MS to understand small molecule target interactions. Candidates will be able to create innovative, goal-focused experiments in a resourceful, self-sufficient manner, then execute them at pace with the support of larger teams. Excellent communications skills, strong teamwork and an ability to adapt to rapidly changing priorities are essential.

Key Responsibilities
  • Develop, optimize and run structural MS experiments
  • Collate and interpret complex data and synthesize results into conclusions or recommendations
  • Perform experimental troubleshooting
  • Identify relevant emerging technologies to advance existing technology platforms and create/maintain a competitive advantage
  • Prepare and present experimental conclusions at internal Group/Department or Project Team research meetings
  • Work closely with colleagues to prioritise and schedule experiments
  • Capture and record experimental outcomes for project updates and compliance needs
  • Contribute to patent and/or publication preparation

  • Knowledge and Skills
  • Practical experience of using HDX or structural MS approaches
  • Desire to push boundaries and develop new methods using HDX and structural MS to solve challenging problems relevant to drug discovery
  • Experience with native mass spectrometry for characterisation of proteins, nucleotides, biotherapeutics or ligand interactions
  • Strong team player, comfortable working at the interface of multiple disciplines
  • Ability to contextualise own experimental work within higher level project goals
  • Show deep understanding of own discipline and the relevant, contemporary academic literature
  • Excellent communication and time management skills

  • Education and Experience:
  • Ph.D. or equivalent industry experience
  • Outstanding communication and team working skills
  • Practical experience working with a variety of MS systems

  • Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Please note that Vertex requires COVID-19 vaccination for all employees working in the U.S. as a condition of employment at Vertex, subject to medical, religious or other accommodations or exemptions required by law. We believe this requirement is vital to keeping everyone at Vertex and in our communities safe. This requirement applies to both existing and new employees who may at any time work on-site at a Vertex facility or visit another location on behalf of Vertex (e.g., conferences, customer visits, etc.), including all remote employees. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition

    Job Information

    • Job ID: 64856860
    • Location:
      Oxford, United Kingdom
    • Company Name For Job: Vertex Pharmaceuticals
    • Position Title: Research Scientist HDX, Structural, Native Mass spectrometry (15 month FTC)
    • Job Function: Other / Not Listed
    • Job Type: Full-Time

    At Vertex, we bring together the brightest minds in the relentless pursuit of creating transformative medicines for people with serious and life-threatening diseases. Founded in 1989 in Cambridge, Massachusetts, we are one of only a handful of biotechnology companies founded since 1976 that has discovered and developed four or more approved medicines in our own labs. In addition to the four medicines we’ve developed to treat the underlying cause of cystic fibrosis, we have ongoing research programs focused on the underlying ...

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